WebAug 24, 2024 · The 3-ketoacyl-CoA thiolase (KAT) is a member of the thiolase, which is capable of catalyzing the Claisen condensation reaction between the two acyl-CoAs, … WebMar 12, 2024 · Another example of a reaction with unfavorable thermodynamics in central carbon metabolism is the nondecarboxylative Claisen condensation of two acetyl-CoA molecules into acetoacetyl-CoA catalyzed by acetoacetyl-CoA thiolases (thiolases); K eq = (1.1 ± 0.2) × 10 −5 (); estimated ΔG°′ = +26.1 kJ/mol using eQuilibrator ().Thiolases …
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WebJan 1, 2014 · There are two major types of thiolases, (i) acyl-CoA:acetyl-CoA C-acyltransferase (EC 2.3.1.16), also named thiolase I or 3-oxoacyl-CoA thiolase, and (ii) … Thiolases, also known as acetyl-coenzyme A acetyltransferases (ACAT), are enzymes which convert two units of acetyl-CoA to acetoacetyl CoA in the mevalonate pathway. Thiolases are ubiquitous enzymes that have key roles in many vital biochemical pathways, including the beta oxidation pathway … See more Thiolases are a family of evolutionarily related enzymes. Two different types of thiolase are found both in eukaryotes and in prokaryotes: acetoacetyl-CoA thiolase (EC 2.3.1.9) and 3-ketoacyl-CoA thiolase (EC 2.3.1.16). … See more Mammalian nonspecific lipid-transfer protein (nsL-TP) (also known as sterol carrier protein 2) is a protein which seems to exist in two … See more Most enzymes of the thiolase superfamily are dimers. However, monomers have not been observed. Tetramers are observed only in the thiolase subfamily and, in these cases, the dimers have dimerized to become tetramers. The crystal structure of the tetrameric … See more • Acetyl-CoA+C-Acetyltransferase at the U.S. National Library of Medicine Medical Subject Headings (MeSH) • Overview of all the structural … See more Thioesters are more reactive than oxygen esters and are common intermediates in fatty-acid metabolism. These thioesters are made by … See more In eukaryotic cells, especially in mammalian cells, thiolases exhibit diversity in intracellular localization related to their metabolic functions as well as in substrate specificity. For … See more Mitochondrial acetoacetyl-CoA thiolase deficiency, known earlier as β-ketothiolase deficiency, is an inborn error of metabolism involving isoleucine catabolism and … See more michael kors smart watch chargers
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WebJan 12, 2024 · Activation of enzymes by monovalent cations (M+) is a widespread phenomenon in biology. Despite this, there are few structure-based studies describing the underlying molecular details. Thiolases are a ubiquitous and highly conserved family of enzymes containing both K+-activated and K+-independent members ... Macromolecules WebThiolases, also known as acetyl-coenzyme A acetyltransferases ( ACAT ), are enzymes which convert two units of acetyl-CoA to acetoacetyl CoA in the mevalonate pathway. WebDec 13, 1999 · 1DLU, 1DLV, 1DM3. PubMed Abstract: Biosynthetic thiolases catalyze the biological Claisen condensation of two acetyl-CoA molecules to form acetoacetyl-CoA. This is one of the fundamental categories of … michael kors smartwatch charger compatibility