Klf6 endothelial
WebFeb 1, 2024 · KLF6 expression in podocytes preserves mitochondrial function and prevents podocyte apoptosis, while KLF5 expression prevents podocyte apoptosis by blockade of ERK/p38 MAPK pathways. KLF15 is a critical regulator of podocyte differentiation and is protective against podocyte injury. WebJan 17, 2024 · KLF6 expression in podocytes preserves mitochondrial function and prevents podocyte apoptosis, while KLF5 expression prevents podocyte apoptosis by blockade of ERK/p38 MAPK pathways. KLF15 is a critical regulator of podocyte differentiation and is …
Klf6 endothelial
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WebJul 1, 2005 · We previously showed that KLF6, a ubiquitously expressed zinc finger transcription factor, is a tumor suppressor gene inactivated by allelic loss and somatic mutation in sporadic prostate cancers that can mediate growth suppression both by a p53-independent, up-regulation of p21 ( 2 ), and by disrupting the interaction between cyclin … WebFeb 5, 2024 · Endothelial KLF6, therefore, may promote immune cell infiltration during vascular injury. In addition to regulating endoglin, KLF6 also induces expression of activin receptor-like kinase 1 (ALK1), another member of the TGF-β receptor family ( 58 ).
WebNov 22, 2024 · In this context, KLF6 expression per se was capable to trigger cellular senescence in both normal and tumoral contexts. As such, the findings presented in this report provide insights into a potential mechanism by which KLF6 may play a suppressing … WebJul 2, 2015 · The participation of endothelial cells in this KLF6-orchestrated regulation is not determined. What is the role of TSP4 in this paracrine signalling then? To demonstrate its causal involvement, Sawaki et al. first showed that culturing fibroblasts on TSP4 attenuated their expression of fibrotic markers under Ang II stimulation. More ...
WebFurthermore, KLF6 markedly increases the transcriptional activity of different reporter constructs of MMP14 gene promoter. These results suggest that KLF6 regulates MMP14 transcription and is a critical player of the gene expression network triggered during endothelial repair. Keywords Endothelial [email protected] Vascular injury WebFurthermore, KLF6 markedly increases the transcriptional activity of different reporter constructs of MMP14 gene promoter. These results suggest that KLF6 regulates MMP14 transcription and is a critical player of the gene expression network triggered during …
WebFeb 5, 2016 · After endothelial injury, the transcription factor Krüppel-like factor 6 (KLF6) translocates into the cell nucleus to regulate a variety of target genes involved in angiogenesis, vascular repair and remodeling, including components of the membrane …
WebJul 28, 2024 · We identify that the klf6a - tagln2 axis regulates CV pruning by promoting endothelial cell rearrangement and junction remodeling. Our results suggest that the caudal vein formation is an ideal model for screening the potential genes involved in vascular remodeling-related disease. Figures markers not crayolaWebSep 8, 2024 · Recently, KLF6 was reported to regulate the expression of CAMs and mediate adhesion between endothelial cells and monocytes [21, 40]. In this study, we found that KLF6 was dramatically downregulated in histamine-treated hNECs but elevated by febuxostat, which is consistent with previous reports [ 21 ]. markers of abuseWebMore recently, KLF6 has been demonstrated to play a role in endothelial cell motility. 112 Farnesoid X Receptor activation leads to the disruption of an SP2/KLF6 repression complex on the matrix metalloproteinase-9 promoter via SHP (small heterodimeric partner). naval postgraduate school letterheadWebFeb 5, 2016 · After endothelial injury, the transcription factor Krüppel-like factor 6 (KLF6) translocates into the cell nucleus to regulate a variety of target genes involved in angiogenesis, vascular repair and remodeling, including components of the membrane transforming growth factor beta (TGF-β) receptor complex such as endoglin and activin … naval postgraduate school homeland securityWebMar 2, 2024 · The KLF6 gene, which belongs to the Krüppel-like family of C2H2 zinc finger TFs, is closely related to the formation, development, and metastasis of tumors in the malignant tumors, including prostate, colon, stomach, liver, lung, neck, pituitary and nervous system [ 15, 16 ]. naval postgraduate school in monterey califWebTherefore, KLF6 in endothelial cells can promote the in ltration of immune cells during vascular injury [15]. However, the role of KLF6 and iNOS in PA supernatant induced macrophage apoptosis is ... markers of akiWebendothelial monolayer at day 6 post-tamoxifen (n=3-4 per genotype). Scale bar is 2 μm. Endothelial cells (EC): red arrowhead, extravascular erythrocytes: white arrow, leucocytes: blue arrow. (A, bottom) Representative pictures of Evans blue vascular permeability assay for the lungs and kidneys at day 6 post-tamoxifen (n=7-8 per genotype). markers not in chromosomal order