High affinity copper uptake protein 1-like

WebCopper (Cu) is an essential trace element for growth and development and abnormal Cu levels are associated with anemia, metabolic disease and cancer. Evolutionarily … Web22 de ago. de 2024 · Crystal structure of the high-affinity copper transporter Ctr1 in complex with Cu (I) PDB DOI: 10.2210/pdb6M98/pdb Classification: TRANSPORT PROTEIN Organism (s): Salmo salar, Escherichia coli Expression System: Komagataella phaffii GS115 Mutation (s): Yes Membrane Protein: Yes PDBTM MemProtMD mpstruc …

High affinity copper uptake protein 1 - Wikiwand

WebCopper is imported into eukaryotic cells through high-affinity copper transporters of the family of Ctr permeases. 9 To date, Ctr transporters are the best-characterized system … Web17 de nov. de 2024 · The expression of the high affinity Cu uptake system is transcriptionally regulated by a copper metalloregulatory transcription factor (CuMRTF) named ScMac1 ( Labbe et al., 1997; Keller et al., 2005 ). In the absence of copper, ScMac1 is able to bind DNA, thereby activating the expression of the high affinity Cu uptake … dwt law firm seattle https://bwautopaint.com

VARIDT: Drug Transporter Database

WebHigh affinity copper uptake protein 1 Gene SLC31A1 Status UniProtKB reviewed (Swiss-Prot) Organism Homo sapiens (Human) Amino acids 190 Protein existence Evidence at … WebCopper is an essential cofactor for key processes in plants, but it exerts harmful effects when in excess. Previous work has shown that the Arabidopsis (Arabidopsis thaliana) COPT1 high-affinity copper transport protein participates in … WebBecause copper uptake at the cell membrane is a crucial step in copper acquisition, yeast genes encoding the high affinity copper transport proteins are tightly regulated in response to copper levels to ensure … dwt listing theme

O15431 - UniProt

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High affinity copper uptake protein 1-like

High affinity copper uptake protein 1 (pig) - PubChem

Web25 de set. de 2024 · Abstract Copper is crucial for carrying out normal physiological functions in all higher life forms. Copper Transporter 1 (CTR1) is the high-affinity copper importer found in all eukaryotic organisms. The copper transporter family primarily comprises ~ six members (CTR1-6) and the related members share high sequence … Web21 de abr. de 2011 · COPT7 alone could mediate a high-affinity Cu uptake in the yeast mutant. None of the seven COPTs alone or in cooperation could complement the phenotypes of S. cerevisiae mutants that lacked the transporter genes either for iron uptake or for zinc uptake.

High affinity copper uptake protein 1-like

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WebCopper uptake transmembrane transporter activity Specific Function High-affinity, saturable copper transporter involved in dietary copper uptake. Pfam Domain Function. … Web1 de abr. de 2024 · Inducible high-affinity copper uptake is key to copper homeostasis in Chlamydomonas reinhardtii. We generated cDNAs and updated gene models for four genes, CTR1, CTR2, CTR3, and COPT1, encoding ...

WebProtein target information for High affinity copper uptake protein 1 (house mouse). Find diseases associated with this biological target and compounds tested against it in … WebIt has been claimed that human copper transporter 1 (hCTR1), the human high-affinity copper transporter, is the major entry pathway for cDDP and related drugs via a mechanism that mimics copper. This is an unexpected property of …

WebProtein High affinity copper uptake protein 1 Gene SLC31A1 Source organism Homo sapiens (Human) go to search UniProt O15431 go to UniProt Experimental structures 3 … Web13 de abr. de 2024 · Expression and affinity purification of recombinant proteins. Recombinant proteins were purified by Ni-NTA affinity column (detected by western blot). The gel was stained with Coomassie brilliant blue G250 (CBB G250). (A) Western blot analyses of the recombinant Rh14-3-3ζ and Rh14-3-3ε protein.

Web7 de mai. de 2024 · Cuprizone administration induces mitochondrial enlargement, severely alters metabolic rates, and impairs oxidative phosphorylation by reducing mitochondrial enzymes that contain copper as a cofactor, such as monoamine oxidase [ 27] and cytochrome c (Cyt c) oxidase [ 28, 29] in the brain of mice.

http://varidt.idrblab.net/ crystallopathyとはWebHigh affinity copper uptake protein 1 Kind protein Organism Humans Protein. Name UniProt ID; High affinity copper uptake protein 1: O15431: Details: Drug Relations … crystal lopez instagramWebThese high-affinity copper transporters exist in all eukaryotes and their discovery has provided new insights into how cells acquire and regulate this essential nutrient. The … crystallophilusWebTransport of ferrous iron (Fe 2+). Fe 2+ uptake is carried out by proteins involved in high-affinity uptake systems and general divalent metal ion transporters. The two most widely distributed eukaryotic divalent metal-ion uptake protein families are Natural Resistance Associated Protein (NRAMP) and Zinc-Regulated Transporter (ZRT)-Iron-Regulated … crystallo paphosWebHigh affinity copper uptake protein 1: Synonyms: Copper transporter 1; Solute carrier family 31 member 1; hCTR1; Gene Name: SLC31A1: Protein Type: Transporter: Biological Properties; ... structure of the human copper transporter CTR1 at 6-A resolution reveals a compact trimer with a novel channel-like architecture. crystal look blindsWebThe affinity measured by Km value for the drugs transported by their corresponding DTs were unified to the unit of micromolar 4. 2D and 3D Structures of Small Molecular Drugs The structures of the small molecular drugs transported by DTs were drawn and were standardized in the .sdf format (both 2D and 3D) 5. crystallopathyWeb28 de nov. de 2024 · DOI: 10.3389/fmolb.2024.1055356 Abstract More than a decade ago, studies on cellular cisplatin accumulation via active membrane transport established the role of the high affinity copper uptake protein 1 (CTR1) as a main uptake route besides passive diffusion. dwt marineworkshop