WebThe relationship of FOXM1 expression and clinicopathological features of NSCLC patients was evaluated by us. In addition, we also explored the biological functions of FOXM1 in NSCLC cell lines. Results: The FOXM1 is highly expressed in NSCLC tissues and cell lines. FOXM1 expression was closely correlated with lymph node status and TNM stage. WebIn CTC-ITB-01 cells, FOXM1 knockdown induced cell death as monitored by PARP1 and caspase-7 cleavage and through colony-forming assays (Figure 3C). In MCF7 cells, FOXM1 knockdown led to a slight increase in PARP1 and caspase-7 cleavage (Figure 3D, upper panel) and decreased outgrowth of colonies (Figure 3D, lower panel).
Centromere protein U expression promotes non-small-cell lung …
WebJun 14, 2024 · Abstract. FOXM1 is a transcription factor of the Forkhead family that is required for cell proliferation of normal cells. However, FOXM1 is repeatedly … WebThe relationship between FoxM1 expression and clinicopathological features in patients with HCC. As shown in Table 1, the relationship between the FoxM1 expression and the clinicopathological features of HCC was established in this meta-analysis.Seven studies comprising 1,659 patients were used to evaluate the difference in FoxM1 expression … overflow period
The transcription factor FOXM1 (Forkhead box M1 ... - PubMed
WebSep 12, 2024 · FOXM1 (forkhead box protein M1) is a critical proliferation-associated transcription factor that is widely spatiotemporally expressed … FOXM1 is known to play a key role in cell cycle progression where endogenous FOXM1 expression peaks at S and G2/M phases. FOXM1-null mouse embryos were neonatal lethal as a result of the development of polyploid cardiomyocytes and hepatocytes, highlighting the role of FOXM1 in mitotic division. More recently a study using transgenic/knockout mouse embryonic fibroblasts and human osteosarcoma cells (U2OS) has shown that FOXM1 regulates expression … WebDec 2, 2024 · FoxO3 and FoxM1 function downstream of PI3K-Akt, whilst Ras-ERK and JNK/p38MAPK signaling pathways are crucial for cell survival, proliferation, differentiation, and cell cycle control. This chemotherapeutic agent influences cellular toxicity through FOXO3 and FoxM1 signaling, affecting cell survival, proliferation, differentiation via cell ... overflow pfp